Integrated Approaches to Drug Discovery for Oxidative Stress-Related Retinal Diseases

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Integrated Approaches to Drug Discovery for Oxidative Stress-Related Retinal Diseases

Excessive oxidative stress induces dysregulation of functional networks in the retina, resulting in retinal diseases such as glaucoma, age-related macular degeneration, and diabetic retinopathy. Although various therapies have been developed to reduce oxidative stress in retinal diseases, most have failed to show efficacy in clinical trials. This may be due to oversimplification of target selec...

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Oxidative Stress in Retinal Diseases

1Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Mie 514-8507, Japan 2Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu 501-1196, Japan 3Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan 4Department of Ophthal...

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ژورنال

عنوان ژورنال: Oxidative Medicine and Cellular Longevity

سال: 2016

ISSN: 1942-0900,1942-0994

DOI: 10.1155/2016/2370252